Vaccines for gay and bi men: hepatitis A and B, HPV, mpox
Definition : Four vaccines are recommended for men who have sex with men to protect against sexually transmitted infections: hepatitis A, hepatitis B, HPV (up to 26 in France) and mpox.
- Keywords
- vaccines, MSM vaccination, hepatitis A vaccine, hepatitis B vaccine, HPV vaccine, mpox vaccine
- Topics
- Sexual Health & Prevention
- Updated

Why get vaccinated as a man who has sex with men?
Because several infections that circulate widely between men are vaccine-preventable, which isn’t true of syphilis, gonorrhoea or chlamydia. Sexosafe (Santé publique France) talks about 3 essential vaccines (hepatitis A, hepatitis B, HPV), plus mpox since 2022.
Hepatitis A
- Why: spread by faecal-oral contact, notably rimming and anal play.
- Schedule: one injection protects after about a month; a second dose gives lasting protection.
- Details: hepatitis A.
Hepatitis B
- Why: highly infectious through semen and blood; can become chronic.
- Schedule: 3 injections. According to WHO the vaccine gives almost 100% protection, for at least 20 years and probably for life.
- Details: hepatitis B.
A combined A + B vaccine exists: handy for doing both at once.
HPV (papillomavirus)
- Why: prevents warts and anal and throat cancers.
- Who: recommended in France for men who have sex with men up to age 26, reimbursed by health insurance.
- Details: HPV.
Mpox
- Who: MSM and trans people with several partners, sex workers, people working in sex-on-premises venues; no proof required.
- Schedule: 2 doses 28 days apart (only 1 if vaccinated against smallpox before 1980), booster after 2 years.
- Details: mpox.
Where to get vaccinated and what does it cost (France)?
- At a CeGIDD clinic: Sexosafe says vaccines are covered there; it’s often the easiest option, alongside a test (CeGIDD).
- At your GP or pharmacy (on prescription depending on the vaccine), reimbursed by health insurance.
- During PrEP check-ups: hepatitis A and B vaccination is part of the follow-up.
Once vaccinated?
Sexosafe says that for hepatitis A and B, once the full course is complete, protection lasts for life, with no booster. To know where you stand (vaccinated as a child? past infection?), a simple blood test is enough. Keep a record of your vaccines.
Other useful vaccines?
Ask your doctor about routine vaccines too (diphtheria-tetanus-polio, flu, Covid), and, if you live with HIV, pneumococcus and meningococcus.
Informational article based on official sources. It does not replace medical advice: if in doubt, if you have symptoms or took a risk, see a health professional or a sexual health clinic.
Sources
Figures and recommendations checked against:
- Santé publique France (Sexosafe) — Sexe entre hommes : les 3 vaccins incontournables
- Santé publique France (Sexosafe) — Vaccination Mpox (variole du singe)
- World Health Organization (WHO) — Hepatitis B – fact sheet (updated 28 July 2026)
- World Health Organization (WHO) — Human papillomavirus and cancer – fact sheet (5 March 2024)